Multiple Comparisons Procedures

Multiple comparisons procedures.

In biomedical research, a common question posed by investigators is whether or not an outcome of interest differs significantly between multiple independent groups of subjects in the study sample. For example, in a randomized clinical trial focusing on differences in a parameter of cardiovascular health such as systolic blood pressure or heart rate that is measured on a continuum, one might mak...

I I Simultaneous Test Procedures - Some Theory of Multiple Comparisons

Pairwise multiple comparisons: a model comparison approach versus stepwise procedures.

Researchers in the behavioural sciences have been presented with a host of pairwise multiple comparison procedures that attempt to obtain an optimal combination of Type I error control, power, and ease of application. However, these procedures share one important limitation: intransitive decisions. Moreover, they can be characterized as a piecemeal approach to the problem rather than a holistic...

Multiple comparisons

While multiple testing procedures have been the focus of much statistical research, an important facet of the problem is how to deal with possible confounding. Procedures have been developed by authors in genetics and statistics. In this chapter, we relate these proposals. We propose two new multiple testing approaches within this framework. The first combines sensitivity analysis methods with ...

Sample size determination for step-down multiple test procedures: Orthogonal contrasts and comparisons with a control

Abstrucr; We address the problem of sample size determination for step-down multiple comparison procedures (MCP’s) for two nonhierarchical families orthogonal contrasts and comparisons with a control, in order to guarantee a specified requirement on their power. The results for the corresponding single-step MCP’s are obtained as special cases. Numerical calculations of the sample sizes to guara...